منابع مشابه
Targeted therapy in lymphoma
Discovery of new treatments for lymphoma that prolong survival and are less toxic than currently available agents represents an urgent unmet need. We now have a better understanding of the molecular pathogenesis of lymphoma, such as aberrant signal transduction pathways, which have led to the discovery and development of targeted therapeutics. The ubiquitin-proteasome and the Akt/mammalian targ...
متن کاملTargeted therapy in relapsed classical hodgkin lymphoma.
Although frontline treatment of advanced Hodgkin lymphoma (HL) produces high cure rates, disease either will not respond to or will relapse after initial therapy in approximately a quarter of patients. Many patients with disease relapse can be successfully salvaged with second-line chemotherapy followed by autologous stem cell transplantation (ASCT). Patients whose disease relapses after ASCT a...
متن کاملToward autophagy-targeted therapy in lymphoma.
parameters, which did not show significant associations with early HD. Furthermore, the analysis of data from clinical trials, which involve patient selection, may not be generalizable to the entire APL population. Despite these limitations, this is the largest data set of patients and clinical outcomes in APL that is available at this time. The clear-cut primary end point of early HD in this s...
متن کاملNovel Targeted Agents in Hodgkin and Non-Hodgkin Lymphoma Therapy
There has been a recent emergence of novel targeted agents for treatment of Hodgkin and non-Hodgkin lymphoma. In particular, antibodies and antibody-drug conjugates directed against surface antigens, agents that block immune checkpoint pathways, and small molecule inhibitors directed against cell signaling pathways have shown significant promise in patients with relapsed and refractory disease ...
متن کاملDenileukin diftitox as novel targeted therapy in non-Hodgkin's lymphoma.
Non-Hodgkin's lymphoma (NHL) is a complex group of hematologic malignancies. The majority are B-cell lineage, with 10%-20% arising from T-cell lineage. Detailed knowledge of the subtypes and staging of NHL is essential to plan treatment and provide effective management of treatment-related side effects. Although numerous regimens have demonstrated efficacy in the treatment of NHL, some subtypes...
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ژورنال
عنوان ژورنال: Journal of Hematology & Oncology
سال: 2010
ISSN: 1756-8722
DOI: 10.1186/1756-8722-3-45